Homeobox protein DLX-3 (DLX3)

About Homeobox protein DLX-3

Homeobox protein DLX-3 (DLX3) is a protein from Homo sapiens identified by UniProt accession O60479, 287 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.

Target properties

Protein name	Homeobox protein DLX-3
UniProt accession	O60479
Gene	DLX3
Organism	Homo sapiens
Length	287 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (87)

Diseases linked to this target (Open Targets).

hypomaturation-hypoplastic amelogenesis imperfecta with taurodontism · score 0.71
tricho-dento-osseous syndrome · score 0.69
amelogenesis imperfecta · score 0.50
genetic disorder · score 0.34
Uterine leiomyoma · score 0.27
Peripheral pulmonary artery stenosis · score 0.26
heel bone mineral density · score 0.20
blood urea nitrogen measurement · score 0.16
balding measurement · score 0.14
serum urea measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60479-F1	alphafold	PREDICTED	60.15	—

Amino-acid sequence (287 residues)

MSGSFDRKLS SILTDISSSL SCHAGSKDSP TLPESSVTDL GYYSAPQHDY YSGQPYGQTV NPYTYHHQFN LNGLAGTGAY SPKSEYTYGA SYRQYGAYRE QPLPAQDPVS VKEEPEAEVR MVNGKPKKVR KPRTIYSSYQ LAALQRRFQK AQYLALPERA ELAAQLGLTQ TQVKIWFQNR RSKFKKLYKN GEVPLEHSPN NSDSMACNSP PSPALWDTSS HSTPAPARSQ LPPPLPYSAS PSYLDDPTNS WYHAQNLSGP HLQQQPPQPA TLHHASPGPP PNPGAVY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards