About Myelin protein zero-like protein 2
Myelin protein zero-like protein 2 (MPZL2) is a protein
from Homo sapiens identified by UniProt accession
O60487, 215 residues long.
MolForge cross-references it against 0 known binders and
121 disease associations.
Target properties
| Protein name | Myelin protein zero-like protein 2 |
|---|
| UniProt accession | O60487 |
|---|
| Gene | MPZL2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 215 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (121)
Diseases linked to this target (Open Targets).
- hearing loss, autosomal recessive · score 0.70
- nonsyndromic genetic hearing loss · score 0.37
- non-small cell lung carcinoma · score 0.20
- genetic disorder · score 0.19
- erythrocyte count · score 0.18
- lung adenocarcinoma · score 0.18
- red blood cell density measurement · score 0.15
- hematocrit · score 0.14
- hemoglobin measurement · score 0.14
- uric acid measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60487-F1 | alphafold | PREDICTED | 89.37 | — |
Amino-acid sequence (215 residues)
MYGKSSTRAV LLLLGIQLTA LWPIAAVEIY TSRVLEAVNG TDARLKCTFS SFAPVGDALT VTWNFRPLDG GPEQFVFYYH IDPFQPMSGR FKDRVSWDGN PERYDASILL WKLQFDDNGT YTCQVKNPPD VDGVIGEIRL SVVHTVRFSE IHFLALAIGS ACALMIIIVI VVVLFQHYRK KRWAERAHKV VEIKSKEEER LNQEKKVSVY LEDTD
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