About Long-chain-fatty-acid--CoA ligase 4
Long-chain-fatty-acid--CoA ligase 4 (ACSL4) is a protein
from Homo sapiens identified by UniProt accession
O60488, 711 residues long.
MolForge cross-references it against 0 known binders and
331 disease associations.
Target properties
| Protein name | Long-chain-fatty-acid--CoA ligase 4 |
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| UniProt accession | O60488 |
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| Gene | ACSL4 |
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| Organism | Homo sapiens |
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| Length | 711 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (331)
Diseases linked to this target (Open Targets).
- X-linked non-syndromic intellectual disability · score 0.72
- neurodegenerative disease · score 0.54
- Alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome · score 0.51
- Alport syndrome - intellectual disability - midface hypoplasia - elliptocytosis · score 0.42
- non-syndromic X-linked intellectual disability · score 0.41
- Parkinson disease · score 0.37
- multiple sclerosis · score 0.37
- lysosomal storage disease · score 0.37
- Alzheimer disease · score 0.37
- Intellectual disability · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60488-F1 | alphafold | PREDICTED | 90.40 | — |
Amino-acid sequence (711 residues)
MKLKLNVLTI ILLPVHLLIT IYSALIFIPW YFLTNAKKKN AMAKRIKAKP TSDKPGSPYR SVTHFDSLAV IDIPGADTLD KLFDHAVSKF GKKDSLGTRE ILSEENEMQP NGKVFKKLIL GNYKWMNYLE VNRRVNNFGS GLTALGLKPK NTIAIFCETR AEWMIAAQTC FKYNFPLVTL YATLGKEAVV HGLNESEASY LITSVELLES KLKTALLDIS CVKHIIYVDN KAINKAEYPE GFEIHSMQSV EELGSNPENL GIPPSRPTPS DMAIVMYTSG STGRPKGVMM HHSNLIAGMT GQCERIPGLG PKDTYIGYLP LAHVLELTAE ISCFTYGCRI GYSSPLTLSD QSSKIKKGSK GDCTVLKPTL MAAVPEIMDR IYKNVMSKVQ EMNYIQKTLF KIGYDYKLEQ IKKGYDAPLC NLLLFKKVKA LLGGNVRMML SGGAPLSPQT HRFMNVCFCC PIGQGYGLTE SCGAGTVTEV TDYTTGRVGA PLICCEIKLK DWQEGGYTIN DKPNPRGEIV IGGQNISMGY FKNEEKTAED YSVDENGQRW FCTGDIGEFH PDGCLQIIDR KKDLVKLQAG EYVSLGKVEA ALKNCPLIDN ICAFAKSDQS YVISFVVPNQ KRLTLLAQQK GVEGTWVDIC NNPAMEAEIL KEIREAANAM KLERFEIPIK VRLSPEPWTP ETGLVTDAFK LKRKELRNHY LKDIERMYGG K
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