Docking protein 2 (DOK2)

About Docking protein 2

Docking protein 2 (DOK2) is a protein from Homo sapiens identified by UniProt accession O60496, 412 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.

Target properties

Protein name	Docking protein 2
UniProt accession	O60496
Gene	DOK2
Organism	Homo sapiens
Length	412 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (98)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.39
lymphocyte count · score 0.38
platelet count · score 0.35
total blood protein measurement · score 0.35
platelet component distribution width · score 0.35
monocyte count · score 0.35
serum albumin measurement · score 0.34
mean corpuscular volume · score 0.32
eosinophil percentage of leukocytes · score 0.31
leukocyte count · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60496-F1	alphafold	PREDICTED	69.94	—

Amino-acid sequence (412 residues)

MGDGAVKQGF LYLQQQQTFG KKWRRFGASL YGGSDCALAR LELQEGPEKP RRCEAARKVI RLSDCLRVAE AGGEASSPRD TSAFFLETKE RLYLLAAPAA ERGDWVQAIC LLAFPGQRKE LSGPEGKQSR PCMEENELYS SAVTVGPHKE FAVTMRPTEA SERCHLRGSY TLRAGESALE LWGGPEPGTQ LYDWPYRFLR RFGRDKVTFS FEAGRRCVSG EGNFEFETRQ GNEIFLALEE AISAQKNAAP ATPQPQPATI PASLPRPDSP YSRPHDSLPP PSPTTPVPAP RPRGQEGEYA VPFDAVARSL GKNFRGILAV PPQLLADPLY DSIEETLPPR PDHIYDEPEG VAALSLYDSP QEPRGEAWRR QATADRDPAG LQHVQPAGQD FSASGWQPGT EYDNVVLKKG PK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards