About Protein-tyrosine sulfotransferase 1
Protein-tyrosine sulfotransferase 1 (TPST1) is a protein
from Homo sapiens identified by UniProt accession
O60507, 370 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | Protein-tyrosine sulfotransferase 1 |
|---|
| UniProt accession | O60507 |
|---|
| Gene | TPST1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 370 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (61)
Diseases linked to this target (Open Targets).
- circadian rhythm sleep disorder · score 0.27
- leukocyte count · score 0.26
- total blood protein measurement · score 0.26
- body height · score 0.25
- myeloid white cell count · score 0.20
- neutrophil count · score 0.07
- fat body mass · score 0.07
- blood protein measurement · score 0.06
- body weight · score 0.05
- lean body mass · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60507-F1 | alphafold | PREDICTED | 91.64 | — |
Amino-acid sequence (370 residues)
MVGKLKQNLL LACLVISSVT VFYLGQHAME CHHRIEERSQ PVKLESTRTT VRTGLDLKAN KTFAYHKDMP LIFIGGVPRS GTTLMRAMLD AHPDIRCGEE TRVIPRILAL KQMWSRSSKE KIRLDEAGVT DEVLDSAMQA FLLEIIVKHG EPAPYLCNKD PFALKSLTYL SRLFPNAKFL LMVRDGRASV HSMISRKVTI AGFDLNSYRD CLTKWNRAIE TMYNQCMEVG YKKCMLVHYE QLVLHPERWM RTLLKFLQIP WNHSVLHHEE MIGKAGGVSL SKVERSTDQV IKPVNVGALS KWVGKIPPDV LQDMAVIAPM LAKLGYDPYA NPPNYGKPDP KIIENTRRVY KGEFQLPDFL KEKPQTEQVE
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