Pre-mRNA-processing factor 17 (CDC40)

About Pre-mRNA-processing factor 17

Pre-mRNA-processing factor 17 (CDC40) is a protein from Homo sapiens identified by UniProt accession O60508, 579 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.

Target properties

Protein name	Pre-mRNA-processing factor 17
UniProt accession	O60508
Gene	CDC40
Organism	Homo sapiens
Length	579 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (13)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
pontocerebellar hypoplasia · score 0.26
Non-syndromic pontocerebellar hypoplasia · score 0.26
PHF-tau measurement · score 0.15
blood protein measurement · score 0.08
hepatocellular carcinoma · score 0.07
Microcephaly · score 0.01
Alzheimer disease · score 0.01
neoplasm · score 0.00
cancer · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60508-F1	alphafold	PREDICTED	85.81	—

Amino-acid sequence (579 residues)

MSAAIAALAA SYGSGSGSES DSDSESSRCP LPAADSLMHL TKSPSSKPSL AVAVDSAPEV AVKEDLETGV HLDPAVKEVQ YNPTYETMFA PEFGPENPFR TQQMAAPRNM LSGYAEPAHI NDFMFEQQRR TFATYGYALD PSLDNHQVSA KYIGSVEEAE KNQGLTVFET GQKKTEKRKK FKENDASNID GFLGPWAKYV DEKDVAKPSE EEQKELDEIT AKRQKKGKQE EEKPGEEKTI LHVKEMYDYQ GRSYLHIPQD VGVNLRSTMP PEKCYLPKKQ IHVWSGHTKG VSAVRLFPLS GHLLLSCSMD CKIKLWEVYG ERRCLRTFIG HSKAVRDICF NTAGTQFLSA AYDRYLKLWD TETGQCISRF TNRKVPYCVK FNPDEDKQNL FVAGMSDKKI VQWDIRSGEI VQEYDRHLGA VNTIVFVDEN RRFVSTSDDK SLRVWEWDIP VDFKYIAEPS MHSMPAVTLS PNGKWLACQS MDNQILIFGA QNRFRLNKKK IFKGHMVAGY ACQVDFSPDM SYVISGDGNG KLNIWDWKTT KLYSRFKAHD KVCIGAVWHP HETSKVITCG WDGLIKLWD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards