Beta-1,4-galactosyltransferase 3 (B4GALT3)

About Beta-1,4-galactosyltransferase 3

Beta-1,4-galactosyltransferase 3 (B4GALT3) is a protein from Homo sapiens identified by UniProt accession O60512, 393 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.

Target properties

Protein name	Beta-1,4-galactosyltransferase 3
UniProt accession	O60512
Gene	B4GALT3
Organism	Homo sapiens
Length	393 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (50)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.40
Alzheimer disease · score 0.14
family history of Alzheimer’s disease · score 0.12
waist-hip ratio · score 0.09
neoplasm · score 0.08
Dementia · score 0.08
asthma · score 0.06
monocyte percentage of leukocytes · score 0.05
allergic rhinitis · score 0.05
Eczematoid dermatitis · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60512-F1	alphafold	PREDICTED	88.22	—

Amino-acid sequence (393 residues)

MLRRLLERPC TLALLVGSQL AVMMYLSLGG FRSLSALFGR DQGPTFDYSH PRDVYSNLSH LPGAPGGPPA PQGLPYCPER SPLLVGPVSV SFSPVPSLAE IVERNPRVEP GGRYRPAGCE PRSRTAIIVP HRAREHHLRL LLYHLHPFLQ RQQLAYGIYV IHQAGNGTFN RAKLLNVGVR EALRDEEWDC LFLHDVDLLP ENDHNLYVCD PRGPRHVAVA MNKFGYSLPY PQYFGGVSAL TPDQYLKMNG FPNEYWGWGG EDDDIATRVR LAGMKISRPP TSVGHYKMVK HRGDKGNEEN PHRFDLLVRT QNSWTQDGMN SLTYQLLARE LGPLYTNITA DIGTDPRGPR APSGPRYPPG SSQAFRQEML QRRPPARPGP LSTANHTALR GSH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards