Eukaryotic translation initiation factor 4E-binding…

About Eukaryotic translation initiation factor 4E-binding protein 3

Eukaryotic translation initiation factor 4E-binding protein 3 (EIF4EBP3) is a protein from Homo sapiens identified by UniProt accession O60516, 100 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Eukaryotic translation initiation factor 4E-binding protein 3
UniProt accession	O60516
Gene	EIF4EBP3
Organism	Homo sapiens
Length	100 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

white matter microstructure measurement · score 0.07
blood protein measurement · score 0.06
attention deficit hyperactivity disorder · score 0.05
cancer · score 0.05
schizophrenia 15 · score 0.04
aspartate aminotransferase measurement · score 0.04
body height · score 0.04
autoimmune thrombocytopenic purpura · score 0.03
monocyte count · score 0.03
hereditary thrombophilia due to congenital protein C deficiency · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60516-F1	alphafold	PREDICTED	76.25	—

Amino-acid sequence (100 residues)

MSTSTSCPIP GGRDQLPDCY STTPGGTLYA TTPGGTRIIY DRKFLLECKN SPIARTPPCC LPQIPGVTTP PTAPLSKLEE LKEQETEEEI PDDAQFEMDI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Eukaryotic translation initiation factor 4E-binding protein 3 (EIF4EBP3)