cAMP-responsive element-binding protein-like 2…

About cAMP-responsive element-binding protein-like 2

cAMP-responsive element-binding protein-like 2 (CREBL2) is a protein from Homo sapiens identified by UniProt accession O60519, 120 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	cAMP-responsive element-binding protein-like 2
UniProt accession	O60519
Gene	CREBL2
Organism	Homo sapiens
Length	120 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

monocyte count · score 0.35
systemic lupus erythematosus · score 0.29
testosterone measurement · score 0.24
birth weight · score 0.08
leukocyte count · score 0.03
ovarian carcinoma · score 0.02
Ovarian Endometrioid Adenocarcinoma · score 0.00
cancer · score 0.00
neoplasm · score 0.00
adrenal cortex carcinoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60519-F1	alphafold	PREDICTED	75.66	—

Amino-acid sequence (120 residues)

MDDSKVVGGK VKKPGKRGRK PAKIDLKAKL ERSRQSAREC RARKKLRYQY LEELVSSRER AICALREELE MYKQWCMAMD QGKIPSEIKA LLTGEEQNKS QQNSSRHTKA GKTDANSNSW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

cAMP-responsive element-binding protein-like 2 (CREBL2)