GDP-mannose 4,6 dehydratase (GMDS)

About GDP-mannose 4,6 dehydratase

GDP-mannose 4,6 dehydratase (GMDS) is a protein from Homo sapiens identified by UniProt accession O60547, 372 residues long. MolForge cross-references it against 0 known binders and 364 disease associations.

Target properties

Protein name	GDP-mannose 4,6 dehydratase
UniProt accession	O60547
Gene	GMDS
Organism	Homo sapiens
Length	372 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (364)

Diseases linked to this target (Open Targets).

body height · score 0.52
heel bone mineral density · score 0.50
intraocular pressure measurement · score 0.49
hematocrit · score 0.49
hemoglobin measurement · score 0.49
erythrocyte count · score 0.46
lean body mass · score 0.46
urate measurement · score 0.45
vital capacity · score 0.45
fat body mass · score 0.44

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60547-F1	alphafold	PREDICTED	94.12	—

Amino-acid sequence (372 residues)

MAHAPARCPS ARGSGDGEMG KPRNVALITG ITGQDGSYLA EFLLEKGYEV HGIVRRSSSF NTGRIEHLYK NPQAHIEGNM KLHYGDLTDS TCLVKIINEV KPTEIYNLGA QSHVKISFDL AEYTADVDGV GTLRLLDAVK TCGLINSVKF YQASTSELYG KVQEIPQKET TPFYPRSPYG AAKLYAYWIV VNFREAYNLF AVNGILFNHE SPRRGANFVT RKISRSVAKI YLGQLECFSL GNLDAKRDWG HAKDYVEAMW LMLQNDEPED FVIATGEVHS VREFVEKSFL HIGKTIVWEG KNENEVGRCK ETGKVHVTVD LKYYRPTEVD FLQGDCTKAK QKLNWKPRVA FDELVREMVH ADVELMRTNP NA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards