Forkhead box protein D2 (FOXD2)

About Forkhead box protein D2

Forkhead box protein D2 (FOXD2) is a protein from Homo sapiens identified by UniProt accession O60548, 495 residues long. MolForge cross-references it against 0 known binders and 212 disease associations.

Target properties

Protein name	Forkhead box protein D2
UniProt accession	O60548
Gene	FOXD2
Organism	Homo sapiens
Length	495 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (212)

Diseases linked to this target (Open Targets).

body height · score 0.45
brain volume measurement · score 0.41
neuroimaging measurement · score 0.40
brain measurement · score 0.39
hemoglobin measurement · score 0.39
urinary albumin to creatinine ratio · score 0.39
cortical surface area measurement · score 0.39
cortical thickness · score 0.39
hematocrit · score 0.38
erythrocyte count · score 0.35

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60548-F1	alphafold	PREDICTED	53.99	—

Amino-acid sequence (495 residues)

MTLGSCCCEI MSSESSPAAL SEADADIDVV GGGSGGGELP ARSGPRAPRD VLPHGHEPPA EEAEADLAED EEESGGCSDG EPRALASRGA AAAAGSPGPG AAAARGAAGP GPGPPSGGAA TRSPLVKPPY SYIALITMAI LQSPKKRLTL SEICEFISGR FPYYREKFPA WQNSIRHNLS LNDCFVKIPR EPGNPGKGNY WTLDPESADM FDNGSFLRRR KRFKRQPLPP PHPHPHPHPE LLLRGGAAAA GDPGAFLPGF AAYGAYGYGY GLALPAYGAP PPGPAPHPHP HPHAFAFAAA AAAAPCQLSV PPGRAAAPPP GPPTASVFAG AGSAPAPAPA SGSGPGPGPA GLPAFLGAEL GCAKAFYAAS LSPPAAGTAA GLPTALLRQG LKTDAGGGAG GGGAGAGQRP SFSIDHIMGH GGGGAAPPGA GEGSPGPPFA AAAGPGGQAQ VLAMLTAPAL APVAGHIRLS HPGDALLSSG SRFASKVAGL SGCHF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards