Glycylpeptide N-tetradecanoyltransferase 2 (NMT2)

About Glycylpeptide N-tetradecanoyltransferase 2

Glycylpeptide N-tetradecanoyltransferase 2 (NMT2) is a protein from Homo sapiens identified by UniProt accession O60551, 498 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.

Target properties

Protein name	Glycylpeptide N-tetradecanoyltransferase 2
UniProt accession	O60551
Gene	NMT2
Organism	Homo sapiens
Length	498 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (69)

Diseases linked to this target (Open Targets).

HIV infection · score 0.37
body height · score 0.37
BMI-adjusted hip circumference · score 0.27
chronic kidney disease · score 0.27
Alzheimer disease · score 0.24
Parkinson disease · score 0.24
multiple sclerosis · score 0.24
lysosomal storage disease · score 0.24
neurodegenerative disease · score 0.24
protein measurement · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60551-F1	alphafold	PREDICTED	80.89	—

Amino-acid sequence (498 residues)

MAEDSESAAS QQSLELDDQD TCGIDGDNEE ETEHAKGSPG GYLGAKKKKK KQKRKKEKPN SGGTKSDSAS DSQEIKIQQP SKNPSVPMQK LQDIQRAMEL LSACQGPARN IDEAAKHRYQ FWDTQPVPKL DEVITSHGAI EPDKDNVRQE PYSLPQGFMW DTLDLSDAEV LKELYTLLNE NYVEDDDNMF RFDYSPEFLL WALRPPGWLL QWHCGVRVSS NKKLVGFISA IPANIRIYDS VKKMVEINFL CVHKKLRSKR VAPVLIREIT RRVNLEGIFQ AVYTAGVVLP KPIATCRYWH RSLNPRKLVE VKFSHLSRNM TLQRTMKLYR LPDVTKTSGL RPMEPKDIKS VRELINTYLK QFHLAPVMDE EEVAHWFLPR EHIIDTFVVE SPNGKLTDFL SFYTLPSTVM HHPAHKSLKA AYSFYNIHTE TPLLDLMSDA LILAKSKGFD VFNALDLMEN KTFLEKLKFG IGDGNLQYYL YNWRCPGTDS EKVGLVLQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards