About Gremlin-1
Gremlin-1 (GREM1) is a protein
from Homo sapiens identified by UniProt accession
O60565, 184 residues long.
MolForge cross-references it against 0 known binders and
503 disease associations.
Target properties
| Protein name | Gremlin-1 |
|---|
| UniProt accession | O60565 |
|---|
| Gene | GREM1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 184 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (503)
Diseases linked to this target (Open Targets).
- hereditary mixed polyposis syndrome · score 0.53
- colorectal cancer · score 0.45
- Red cell distribution width · score 0.40
- mean corpuscular volume · score 0.40
- mean corpuscular hemoglobin · score 0.40
- mean corpuscular hemoglobin concentration · score 0.39
- colorectal adenoma · score 0.38
- hypospadias · score 0.31
- synophrys measurement · score 0.31
- cancer · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60565-F1 | alphafold | PREDICTED | 73.51 | — |
Amino-acid sequence (184 residues)
MSRTAYTVGA LLLLLGTLLP AAEGKKKGSQ GAIPPPDKAQ HNDSEQTQSP QQPGSRNRGR GQGRGTAMPG EEVLESSQEA LHVTERKYLK RDWCKTQPLK QTIHEEGCNS RTIINRFCYG QCNSFYIPRH IRKEEGSFQS CSFCKPKKFT TMMVTLNCPE LQPPTKKKRV TRVKQCRCIS IDLD
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