About Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3) is a protein
from Homo sapiens identified by UniProt accession
O60568, 738 residues long.
MolForge cross-references it against 0 known binders and
98 disease associations.
Target properties
| Protein name | Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 |
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| UniProt accession | O60568 |
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| Gene | PLOD3 |
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| Organism | Homo sapiens |
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| Length | 738 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (98)
Diseases linked to this target (Open Targets).
- bone fragility with contractures, arterial rupture, and deafness · score 0.69
- Connective tissue disorder due to lysyl hydroxylase-3 deficiency · score 0.57
- neurodegenerative disease · score 0.45
- Neurodevelopmental delay · score 0.27
- breast adenocarcinoma · score 0.23
- genetic disorder · score 0.19
- contracture · score 0.18
- fetal growth restriction · score 0.18
- intracerebral hemorrhage · score 0.16
- neoplasm · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60568-F1 | alphafold | PREDICTED | 91.35 | — |
Amino-acid sequence (738 residues)
MTSSGPGPRF LLLLPLLLPP AASASDRPRG RDPVNPEKLL VITVATAETE GYLRFLRSAE FFNYTVRTLG LGEEWRGGDV ARTVGGGQKV RWLKKEMEKY ADREDMIIMF VDSYDVILAG SPTELLKKFV QSGSRLLFSA ESFCWPEWGL AEQYPEVGTG KRFLNSGGFI GFATTIHQIV RQWKYKDDDD DQLFYTRLYL DPGLREKLSL NLDHKSRIFQ NLNGALDEVV LKFDRNRVRI RNVAYDTLPI VVHGNGPTKL QLNYLGNYVP NGWTPEGGCG FCNQDRRTLP GGQPPPRVFL AVFVEQPTPF LPRFLQRLLL LDYPPDRVTL FLHNNEVFHE PHIADSWPQL QDHFSAVKLV GPEEALSPGE ARDMAMDLCR QDPECEFYFS LDADAVLTNL QTLRILIEEN RKVIAPMLSR HGKLWSNFWG ALSPDEYYAR SEDYVELVQR KRVGVWNVPY ISQAYVIRGD TLRMELPQRD VFSGSDTDPD MAFCKSFRDK GIFLHLSNQH EFGRLLATSR YDTEHLHPDL WQIFDNPVDW KEQYIHENYS RALEGEGIVE QPCPDVYWFP LLSEQMCDEL VAEMEHYGQW SGGRHEDSRL AGGYENVPTV DIHMKQVGYE DQWLQLLRTY VGPMTESLFP GYHTKARAVM NFVVRYRPDE QPSLRPHHDS STFTLNVALN HKGLDYEGGG CRFLRYDCVI SSPRKGWALL HPGRLTHYHE GLPTTWGTRY IMVSFVDP
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