GDNF family receptor alpha-3 (GFRA3)

About GDNF family receptor alpha-3

GDNF family receptor alpha-3 (GFRA3) is a protein from Homo sapiens identified by UniProt accession O60609, 400 residues long. MolForge cross-references it against 0 known binders and 107 disease associations.

Target properties

Protein name	GDNF family receptor alpha-3
UniProt accession	O60609
Gene	GFRA3
Organism	Homo sapiens
Length	400 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (107)

Diseases linked to this target (Open Targets).

thyroid gland adenocarcinoma · score 0.30
breast adenocarcinoma · score 0.29
lean body mass · score 0.24
fat body mass · score 0.23
whole body water mass · score 0.15
body height · score 0.12
prostate carcinoma · score 0.11
Familial prostate cancer · score 0.11
prostate cancer · score 0.11
appendicular lean mass · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60609-F1	alphafold	PREDICTED	79.00	—

Amino-acid sequence (400 residues)

MVRPLNPRPL PPVVLMLLLL LPPSPLPLAA GDPLPTESRL MNSCLQARRK CQADPTCSAA YHHLDSCTSS ISTPLPSEEP SVPADCLEAA QQLRNSSLIG CMCHRRMKNQ VACLDIYWTV HRARSLGNYE LDVSPYEDTV TSKPWKMNLS KLNMLKPDSD LCLKFAMLCT LNDKCDRLRK AYGEACSGPH CQRHVCLRQL LTFFEKAAEP HAQGLLLCPC APNDRGCGER RRNTIAPNCA LPPVAPNCLE LRRLCFSDPL CRSRLVDFQT HCHPMDILGT CATEQSRCLR AYLGLIGTAM TPNFVSNVNT SVALSCTCRG SGNLQEECEM LEGFFSHNPC LTEAIAAKMR FHSQLFSQDW PHPTFAVMAH QNENPAVRPQ PWVPSLFSCT LPLILLLSLW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards