About Tetraspanin-1
Tetraspanin-1 (TSPAN1) is a protein
from Homo sapiens identified by UniProt accession
O60635, 241 residues long.
MolForge cross-references it against 0 known binders and
98 disease associations.
Target properties
| Protein name | Tetraspanin-1 |
|---|
| UniProt accession | O60635 |
|---|
| Gene | TSPAN1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 241 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (98)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- pachyonychia congenita · score 0.09
- neoplasm · score 0.09
- white matter microstructure measurement · score 0.09
- papillary thyroid carcinoma · score 0.08
- cholangiocarcinoma · score 0.08
- Barrett's esophagus · score 0.08
- endometriosis · score 0.08
- colorectal carcinoma · score 0.08
- head and neck squamous cell carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60635-F1 | alphafold | PREDICTED | 88.21 | — |
Amino-acid sequence (241 residues)
MQCFSFIKTM MILFNLLIFL CGAALLAVGI WVSIDGASFL KIFGPLSSSA MQFVNVGYFL IAAGVVVFAL GFLGCYGAKT ESKCALVTFF FILLLIFIAE VAAAVVALVY TTMAEHFLTL LVVPAIKKDY GSQEDFTQVW NTTMKGLKCC GFTNYTDFED SPYFKENSAF PPFCCNDNVT NTANETCTKQ KAHDQKVEGC FNQLLYDIRT NAVTVGGVAA GIGGLELAAM IVSMYLYCNL Q
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