About Tetraspanin-2
Tetraspanin-2 (TSPAN2) is a protein
from Homo sapiens identified by UniProt accession
O60636, 221 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Tetraspanin-2 |
|---|
| UniProt accession | O60636 |
|---|
| Gene | TSPAN2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 221 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (68)
Diseases linked to this target (Open Targets).
- large artery stroke · score 0.38
- migraine disorder · score 0.36
- Headache · score 0.31
- frozen shoulder · score 0.28
- lymphatic system disease · score 0.28
- vein disorder · score 0.28
- Ischemic stroke · score 0.27
- nervous system disease · score 0.24
- body mass index · score 0.23
- antisocial behaviour measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60636-F1 | alphafold | PREDICTED | 87.40 | — |
Amino-acid sequence (221 residues)
MGRFRGGLRC IKYLLLGFNL LFWLAGSAVI AFGLWFRFGG AIKELSSEDK SPEYFYVGLY VLVGAGALMM AVGFFGCCGA MRESQCVLGS FFTCLLVIFA AEVTTGVFAF IGKGVAIRHV QTMYEEAYND YLKDRGKGNG TLITFHSTFQ CCGKESSEQV QPTCPKELLG HKNCIDEIET IISVKLQLIG IVGIGIAGLT IFGMIFSMVL CCAIRNSRDV I
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