About Tetraspanin-3
Tetraspanin-3 (TSPAN3) is a protein
from Homo sapiens identified by UniProt accession
O60637, 253 residues long.
MolForge cross-references it against 0 known binders and
60 disease associations.
Target properties
| Protein name | Tetraspanin-3 |
|---|
| UniProt accession | O60637 |
|---|
| Gene | TSPAN3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 253 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (60)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.39
- neurodegenerative disease · score 0.33
- BMI-adjusted hip circumference · score 0.31
- appendicular lean mass · score 0.31
- total blood protein measurement · score 0.29
- BMI-adjusted waist circumference · score 0.27
- body height · score 0.22
- eosinophil count · score 0.12
- erythrocyte count · score 0.10
- platelet count · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60637-F1 | alphafold | PREDICTED | 87.04 | — |
Amino-acid sequence (253 residues)
MGQCGITSSK TVLVFLNLIF WGAAGILCYV GAYVFITYDD YDHFFEDVYT LIPAVVIIAV GALLFIIGLI GCCATIRESR CGLATFVIIL LLVFVTEVVV VVLGYVYRAK VENEVDRSIQ KVYKTYNGTN PDAASRAIDY VQRQLHCCGI HNYSDWENTD WFKETKNQSV PLSCCRETAS NCNGSLAHPS DLYAEGCEAL VVKKLQEIMM HVIWAALAFA AIQLLGMLCA CIVLCRRSRD PAYELLITGG TYA
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