About Exocyst complex component 3
Exocyst complex component 3 (EXOC3) is a protein
from Homo sapiens identified by UniProt accession
O60645, 745 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | Exocyst complex component 3 |
|---|
| UniProt accession | O60645 |
|---|
| Gene | EXOC3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 745 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (36)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- hematocrit · score 0.22
- hemoglobin measurement · score 0.21
- erythrocyte count · score 0.20
- endometrial cancer · score 0.18
- red blood cell density measurement · score 0.14
- hypospadias · score 0.13
- squamous cell lung carcinoma · score 0.12
- mean corpuscular hemoglobin concentration · score 0.10
- head and neck squamous cell carcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60645-F1 | alphafold | PREDICTED | 88.51 | — |
Amino-acid sequence (745 residues)
MKETDREAVA TAVQRVAGML QRPDQLDKVE QYRRREARKK ASVEARLKAA IQSQLDGVRT GLSQLHNALN DVKDIQQSLA DVSKDWRQSI NTIESLKDVK DAVVQHSQLA AAVENLKNIF SVPEIVRETQ DLIEQGALLQ AHRKLMDLEC SRDGLMYEQY RMDSGNTRDM TLIHGYFGST QGLSDELAKQ LWMVLQRSLV TVRRDPTLLV SVVRIIEREE KIDRRILDRK KQTGFVPPGR PKNWKEKMFT ILERTVTTRI EGTQADTRES DKMWLVRHLE IIRKYVLDDL IVAKNLMVQC FPPHYEIFKN LLNMYHQALS TRMQDLASED LEANEIVSLL TWVLNTYTST EMMRNVELAP EVDVGTLEPL LSPHVVSELL DTYMSTLTSN IIAWLRKALE TDKKDWVKET EPEADQDGYY QTTLPAIVFQ MFEQNLQVAA QISEDLKTKV LVLCLQQMNS FLSRYKDEAQ LYKEEHLRNR QHPHCYVQYM IAIINNCQTF KESIVSLKRK YLKNEVEEGV SPSQPSMDGI LDAIAKEGCS GLLEEVFLDL EQHLNELMTK KWLLGSNAVD IICVTVEDYF NDFAKIKKPY KKRMTAEAHR RVVVEYLRAV MQKRISFRSP EERKEGAEKM VREAEQLRFL FRKLASGFGE DVDGYCDTIV AVAEVIKLTD PSLLYLEVST LVSKYPDIRD DHIGALLAVR GDASRDMKQT IMETLEQGPA QASPSYVPLF KDIVVPSLNV AKLLK
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