About UDP-glucuronosyltransferase 1A9
UDP-glucuronosyltransferase 1A9 (UGT1A9) is a protein
from Homo sapiens identified by UniProt accession
O60656, 530 residues long.
MolForge cross-references it against 0 known binders and
110 disease associations.
Target properties
| Protein name | UDP-glucuronosyltransferase 1A9 |
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| UniProt accession | O60656 |
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| Gene | UGT1A9 |
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| Organism | Homo sapiens |
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| Length | 530 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (110)
Diseases linked to this target (Open Targets).
- bilirubin measurement · score 0.67
- Gilbert syndrome · score 0.62
- Crigler-Najjar syndrome type 1 · score 0.56
- Crigler-Najjar syndrome type 2 · score 0.55
- Crigler-Najjar syndrome · score 0.53
- transient familial neonatal hyperbilirubinemia · score 0.52
- Hyperbilirubinemia · score 0.51
- porphyrin metabolism disease · score 0.51
- genetic disorder · score 0.49
- trait in response to irinotecan · score 0.48
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60656-F1 | alphafold | PREDICTED | 92.09 | — |
Amino-acid sequence (530 residues)
MACTGWTSPL PLCVCLLLTC GFAEAGKLLV VPMDGSHWFT MRSVVEKLIL RGHEVVVVMP EVSWQLGRSL NCTVKTYSTS YTLEDLDREF KAFAHAQWKA QVRSIYSLLM GSYNDIFDLF FSNCRSLFKD KKLVEYLKES SFDAVFLDPF DNCGLIVAKY FSLPSVVFAR GILCHYLEEG AQCPAPLSYV PRILLGFSDA MTFKERVRNH IMHLEEHLLC HRFFKNALEI ASEILQTPVT EYDLYSHTSI WLLRTDFVLD YPKPVMPNMI FIGGINCHQG KPLPMEFEAY INASGEHGIV VFSLGSMVSE IPEKKAMAIA DALGKIPQTV LWRYTGTRPS NLANNTILVK WLPQNDLLGH PMTRAFITHA GSHGVYESIC NGVPMVMMPL FGDQMDNAKR METKGAGVTL NVLEMTSEDL ENALKAVIND KSYKENIMRL SSLHKDRPVE PLDLAVFWVE FVMRHKGAPH LRPAAHDLTW YQYHSLDVIG FLLAVVLTVA FITFKCCAYG YRKCLGKKGR VKKAHKSKTH
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