About Kelch-like protein 41
Kelch-like protein 41 (KLHL41) is a protein
from Homo sapiens identified by UniProt accession
O60662, 606 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Kelch-like protein 41 |
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| UniProt accession | O60662 |
|---|
| Gene | KLHL41 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 606 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (53)
Diseases linked to this target (Open Targets).
- nemaline myopathy 9 · score 0.74
- nemaline myopathy · score 0.44
- childhood-onset nemaline myopathy · score 0.37
- typical nemaline myopathy · score 0.37
- intermediate nemaline myopathy · score 0.37
- severe congenital nemaline myopathy · score 0.37
- genetic disorder · score 0.19
- myopathy · score 0.05
- autosomal recessive limb-girdle muscular dystrophy type 2L · score 0.04
- Distal myopathy, Nonaka type · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60662-F1 | alphafold | PREDICTED | 93.16 | — |
Amino-acid sequence (606 residues)
MDSQRELAEE LRLYQSTLLQ DGLKDLLDEK KFIDCTLKAG DKSLPCHRLI LSACSPYFRE YFLSEIDEAK KKEVVLDNVD PAILDLIIKY LYSASIDLND GNVQDIFALA SRFQIPSVFT VCVSYLQKRL APGNCLAILR LGLLLDCPRL AISAREFVSD RFVQICKEED FMQLSPQELI SVISNDSLNV EKEEAVFEAV MKWVRTDKEN RVKNLSEVFD CIRFRLMTEK YFKDHVEKDD IIKSNPDLQK KIKVLKDAFA GKLPEPSKNA AKTGAGEVNG DVGDEDLLPG YLNDIPRHGM FVKDLILLVN DTAAVAYDPT ENECYLTALA EQIPRNHSSI VTQQNQIYVV GGLYVDEENK DQPLQSYFFQ LDSIASEWVG LPPLPSARCL FGLGEVDDKI YVVAGKDLQT EASLDSVLCY DPVAAKWNEV KKLPIKVYGH NVISHKGMIY CLGGKTDDKK CTNRVFIFNP KKGDWKDLAP MKIPRSMFGV AVHKGKIVIA GGVTEDGLSA SVEAFDLTTN KWDVMTEFPQ ERSSISLVSL AGSLYAIGGF AMIQLESKEF APTEVNDIWK YEDDKKEWAG MLKEIRYASG ASCLATRLNL FKLSKL
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