LIM homeobox transcription factor 1-beta (LMX1B)

About LIM homeobox transcription factor 1-beta

LIM homeobox transcription factor 1-beta (LMX1B) is a protein from Homo sapiens identified by UniProt accession O60663, 402 residues long. MolForge cross-references it against 0 known binders and 313 disease associations.

Target properties

Protein name	LIM homeobox transcription factor 1-beta
UniProt accession	O60663
Gene	LMX1B
Organism	Homo sapiens
Length	402 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (313)

Diseases linked to this target (Open Targets).

nail-patella syndrome · score 0.85
nail-patella-like renal disease · score 0.68
focal segmental glomerulosclerosis · score 0.61
glaucoma · score 0.54
body mass index · score 0.53
open-angle glaucoma · score 0.53
intraocular pressure measurement · score 0.52
lean body mass · score 0.50
refractive error measurement · score 0.50
body fat percentage · score 0.49

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60663-F1	alphafold	PREDICTED	69.77	—

Amino-acid sequence (402 residues)

MDIATGPESL ERCFPRGQTD CAKMLDGIKM EEHALRPGPA TLGVLLGSDC PHPAVCEGCQ RPISDRFLMR VNESSWHEEC LQCAACQQAL TTSCYFRDRK LYCKQDYQQL FAAKCSGCME KIAPTEFVMR ALECVYHLGC FCCCVCERQL RKGDEFVLKE GQLLCKGDYE KEKDLLSSVS PDESDSVKSE DEDGDMKPAK GQGSQSKGSG DDGKDPRRPK RPRTILTTQQ RRAFKASFEV SSKPCRKVRE TLAAETGLSV RVVQVWFQNQ RAKMKKLARR HQQQQEQQNS QRLGQEVLSS RMEGMMASYT PLAPPQQQIV AMEQSPYGSS DPFQQGLTPP QMPGDHMNPY GNDSIFHDID SDTSLTSLSD CFLGSSDVGS LQARVGNPID RLYSMQSSYF AS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards