Perilipin-3 (PLIN3)

About Perilipin-3

Perilipin-3 (PLIN3) is a protein from Homo sapiens identified by UniProt accession O60664, 434 residues long. MolForge cross-references it against 0 known binders and 103 disease associations.

Target properties

Protein name	Perilipin-3
UniProt accession	O60664
Gene	PLIN3
Organism	Homo sapiens
Length	434 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (103)

Diseases linked to this target (Open Targets).

neoplasm · score 0.09
hepatocellular carcinoma · score 0.08
oral squamous cell carcinoma · score 0.08
metabolite measurement · score 0.07
hypothyroidism · score 0.06
thyroid disease · score 0.05
diabetes mellitus · score 0.04
myxedema · score 0.04
drug use measurement · score 0.04
endocrine system disease · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60664-F1	alphafold	PREDICTED	68.37	—

Amino-acid sequence (434 residues)

MSADGAEADG STQVTVEEPV QQPSVVDRVA SMPLISSTCD MVSAAYASTK ESYPHIKTVC DAAEKGVRTL TAAAVSGAQP ILSKLEPQIA SASEYAHRGL DKLEENLPIL QQPTEKVLAD TKELVSSKVS GAQEMVSSAK DTVATQLSEA VDATRGAVQS GVDKTKSVVT GGVQSVMGSR LGQMVLSGVD TVLGKSEEWA DNHLPLTDAE LARIATSLDG FDVASVQQQR QEQSYFVRLG SLSERLRQHA YEHSLGKLRA TKQRAQEALL QLSQVLSLME TVKQGVDQKL VEGQEKLHQM WLSWNQKQLQ GPEKEPPKPE QVESRALTMF RDIAQQLQAT CTSLGSSIQG LPTNVKDQVQ QARRQVEDLQ ATFSSIHSFQ DLSSSILAQS RERVASAREA LDHMVEYVAQ NTPVTWLVGP FAPGITEKAP EEKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards