Immunoglobulin mu Fc receptor (FCMR)

About Immunoglobulin mu Fc receptor

Immunoglobulin mu Fc receptor (FCMR) is a protein from Homo sapiens identified by UniProt accession O60667, 390 residues long. MolForge cross-references it against 0 known binders and 215 disease associations.

Target properties

Protein name	Immunoglobulin mu Fc receptor
UniProt accession	O60667
Gene	FCMR
Organism	Homo sapiens
Length	390 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (215)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.19
lymphocyte count · score 0.11
common variable immunodeficiency · score 0.09
isolated agammaglobulinemia · score 0.08
neoplasm · score 0.08
immunodeficiency 18 · score 0.07
immunodeficiency 62 · score 0.07
immunodeficiency, common variable, 4 · score 0.07
severe combined immunodeficiency due to CTPS1 deficiency · score 0.06
inborn error of immunity · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60667-F1	alphafold	PREDICTED	64.91	—

Amino-acid sequence (390 residues)

MDFWLWPLYF LPVSGALRIL PEVKVEGELG GSVTIKCPLP EMHVRIYLCR EMAGSGTCGT VVSTTNFIKA EYKGRVTLKQ YPRKNLFLVE VTQLTESDSG VYACGAGMNT DRGKTQKVTL NVHSEYEPSW EEQPMPETPK WFHLPYLFQM PAYASSSKFV TRVTTPAQRG KVPPVHHSSP TTQITHRPRV SRASSVAGDK PRTFLPSTTA SKISALEGLL KPQTPSYNHH TRLHRQRALD YGSQSGREGQ GFHILIPTIL GLFLLALLGL VVKRAVERRK ALSRRARRLA VRMRALESSQ RPRGSPRPRS QNNIYSACPR RARGADAAGT GEAPVPGPGA PLPPAPLQVS ESPWLHAPSL KTSCEYVSLY HQPAAMMEDS DSDDYINVPA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards