Cell cycle checkpoint protein RAD1 (RAD1)

About Cell cycle checkpoint protein RAD1

Cell cycle checkpoint protein RAD1 (RAD1) is a protein from Homo sapiens identified by UniProt accession O60671, 282 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.

Target properties

Protein name	Cell cycle checkpoint protein RAD1
UniProt accession	O60671
Gene	RAD1
Organism	Homo sapiens
Length	282 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (64)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.32
breast adenocarcinoma · score 0.28
lung adenocarcinoma · score 0.28
endometrial cancer · score 0.27
gastric adenocarcinoma · score 0.17
hemolytic anemia due to glutathione reductase deficiency · score 0.05
dehydrated hereditary stomatocytosis · score 0.05
Rh deficiency syndrome · score 0.04
Hemolytic anemia due to red cell pyruvate kinase deficiency · score 0.04
hemolytic anemia due to erythrocyte adenosine deaminase overproduction · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60671-F1	alphafold	PREDICTED	89.42	—

Amino-acid sequence (282 residues)

MPLLTQQIQD EDDQYSLVAS LDNVRNLSTI LKAIHFREHA TCFATKNGIK VTVENAKCVQ ANAFIQAGIF QEFKVQEESV TFRINLTVLL DCLSIFGSSP MPGTLTALRM CYQGYGYPLM LFLEEGGVVT VCKINTQEPE ETLDFDFCST NVINKIILQS EGLREAFSEL DMTSEVLQIT MSPDKPYFRL STFGNAGSSH LDYPKDSDLM EAFHCNQTQV NRYKISLLKP STKALVLSCK VSIRTDNRGF LSLQYMIRNE DGQICFVEYY CCPDEEVPES ES

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards