About Cystatin-8
Cystatin-8 (CST8) is a protein
from Homo sapiens identified by UniProt accession
O60676, 142 residues long.
MolForge cross-references it against 0 known binders and
105 disease associations.
Target properties
| Protein name | Cystatin-8 |
|---|
| UniProt accession | O60676 |
|---|
| Gene | CST8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 142 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (105)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.07
- spermatogenic failure 63 · score 0.06
- congenital bilateral absence of vas deferens · score 0.06
- spermatogenic failure 25 · score 0.06
- spermatogenic failure 65 · score 0.06
- spermatogenic failure 56 · score 0.06
- spermatogenic failures 50 · score 0.06
- spermatogenic failure, X-linked, 3 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60676-F1 | alphafold | PREDICTED | 87.17 | — |
Amino-acid sequence (142 residues)
MPRCRWLSLI LLTIPLALVA RKDPKKNETG VLRKLKPVNA SNANVKQCLW FAMQEYNKES EDKYVFLVVK TLQAQLQVTN LLEYLIDVEI ARSDCRKPLS TNEICAIQEN SKLKRKLSCS FLVGALPWNG EFTVMEKKCE DA
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