About Protein arginine N-methyltransferase 3
Protein arginine N-methyltransferase 3 (PRMT3) is a protein
from Homo sapiens identified by UniProt accession
O60678, 531 residues long.
MolForge cross-references it against 0 known binders and
60 disease associations.
Target properties
| Protein name | Protein arginine N-methyltransferase 3 |
|---|
| UniProt accession | O60678 |
|---|
| Gene | PRMT3 |
|---|
| Organism | Homo sapiens |
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| Length | 531 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (60)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.24
- endometrial cancer · score 0.18
- clear cell renal carcinoma · score 0.18
- carotid artery intima media thickness · score 0.12
- gastric adenocarcinoma · score 0.11
- hepatocellular carcinoma · score 0.10
- neoplasm · score 0.09
- glioblastoma multiforme · score 0.07
- pancreatic neoplasm · score 0.07
- adolescent idiopathic scoliosis · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60678-F1 | alphafold | PREDICTED | 85.08 | — |
Amino-acid sequence (531 residues)
MCSLASGATG GRGAVENEED LPELSDSGDE AAWEDEDDAD LPHGKQQTPC LFCNRLFTSA EETFSHCKSE HQFNIDSMVH KHGLEFYGYI KLINFIRLKN PTVEYMNSIY NPVPWEKEEY LKPVLEDDLL LQFDVEDLYE PVSVPFSYPN GLSENTSVVE KLKHMEARAL SAEAALARAR EDLQKMKQFA QDFVMHTDVR TCSSSTSVIA DLQEDEDGVY FSSYGHYGIH EEMLKDKIRT ESYRDFIYQN PHIFKDKVVL DVGCGTGILS MFAAKAGAKK VLGVDQSEIL YQAMDIIRLN KLEDTITLIK GKIEEVHLPV EKVDVIISEW MGYFLLFESM LDSVLYAKNK YLAKGGSVYP DICTISLVAV SDVNKHADRI AFWDDVYGFK MSCMKKAVIP EAVVEVLDPK TLISEPCGIK HIDCHTTSIS DLEFSSDFTL KITRTSMCTA IAGYFDIYFE KNCHNRVVFS TGPQSTKTHW KQTVFLLEKP FSVKAGEALK GKVTVHKNKK DPRSLTVTLT LNNSTQTYGL Q
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