Peroxisome biogenesis factor 10 (PEX10)

About Peroxisome biogenesis factor 10

Peroxisome biogenesis factor 10 (PEX10) is a protein from Homo sapiens identified by UniProt accession O60683, 326 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.

Target properties

Protein name	Peroxisome biogenesis factor 10
UniProt accession	O60683
Gene	PEX10
Organism	Homo sapiens
Length	326 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (50)

Diseases linked to this target (Open Targets).

peroxisome biogenesis disorder 6B · score 0.79
peroxisome biogenesis disorder 6A (Zellweger) · score 0.77
Zellweger syndrome · score 0.73
peroxisome biogenesis disorder · score 0.66
peroxisome biogenesis disorder, complementation group 7 · score 0.65
Peroxisome biogenesis disorder-Zellweger syndrome spectrum · score 0.57
Zellweger spectrum disorders · score 0.52
genetic disorder · score 0.47
autosomal recessive ataxia due to PEX10 deficiency · score 0.37
spastic ataxia · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60683-F1	alphafold	PREDICTED	82.51	—

Amino-acid sequence (326 residues)

MAPAAASPPE VIRAAQKDEY YRGGLRSAAG GALHSLAGAR KWLEWRKEVE LLSDVAYFGL TTLAGYQTLG EEYVSIIQVD PSRIHVPSSL RRGVLVTLHA VLPYLLDKAL LPLEQELQAD PDSGRPLQGS LGPGGRGCSG ARRWMRHHTA TLTEQQRRAL LRAVFVLRQG LACLQRLHVA WFYIHGVFYH LAKRLTGITY LRVRSLPGED LRARVSYRLL GVISLLHLVL SMGLQLYGFR QRQRARKEWR LHRGLSHRRA SLEERAVSRN PLCTLCLEER RHPTATPCGH LFCWECITAW CSSKAECPLC REKFPPQKLI YLRHYR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards