About Importin subunit alpha-7
Importin subunit alpha-7 (KPNA6) is a protein
from Homo sapiens identified by UniProt accession
O60684, 536 residues long.
MolForge cross-references it against 0 known binders and
209 disease associations.
Target properties
| Protein name | Importin subunit alpha-7 |
|---|
| UniProt accession | O60684 |
|---|
| Gene | KPNA6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 536 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (209)
Diseases linked to this target (Open Targets).
- Female infertility due to fertilization defect · score 0.10
- Rare genetic female infertility · score 0.09
- azoospermia · score 0.09
- female infertility due to oocyte meiotic arrest · score 0.09
- female infertility due to zona pellucida defect · score 0.09
- oocyte maturation defect 11 · score 0.09
- spermatogenic failure 8 · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- partial chromosome Y deletion · score 0.08
- Hydatidiform Mole · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60684-F1 | alphafold | PREDICTED | 86.68 | — |
Amino-acid sequence (536 residues)
METMASPGKD NYRMKSYKNN ALNPEEMRRR REEEGIQLRK QKREQQLFKR RNVELINEEA AMFDSLLMDS YVSSTTGESV ITREMVEMLF SDDSDLQLAT TQKFRKLLSK EPSPPIDEVI NTPRVVDRFV EFLKRNENCT LQFEAAWALT NIASGTSQQT KIVIEAGAVP IFIELLNSDF EDVQEQAVWA LGNIAGDSSV CRDYVLNCSI LNPLLTLLTK STRLTMTRNA VWALSNLCRG KNPPPEFAKV SPCLPVLSRL LFSSDSDLLA DACWALSYLS DGPNEKIQAV IDSGVCRRLV ELLMHNDYKV ASPALRAVGN IVTGDDIQTQ VILNCSALPC LLHLLSSPKE SIRKEACWTI SNITAGNRAQ IQAVIDANIF PVLIEILQKA EFRTRKEAAW AITNATSGGT PEQIRYLVSL GCIKPLCDLL TVMDSKIVQV ALNGLENILR LGEQEGKRSG SGVNPYCGLI EEAYGLDKIE FLQSHENQEI YQKAFDLIEH YFGVEDDDSS LAPQVDETQQ QFIFQQPEAP MEGFQL
Explore Importin subunit alpha-7 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets