UDP-glucose 6-dehydrogenase (UGDH)

About UDP-glucose 6-dehydrogenase

UDP-glucose 6-dehydrogenase (UGDH) is a protein from Homo sapiens identified by UniProt accession O60701, 494 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.

Target properties

Protein name	UDP-glucose 6-dehydrogenase
UniProt accession	O60701
Gene	UGDH
Organism	Homo sapiens
Length	494 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (98)

Diseases linked to this target (Open Targets).

developmental and epileptic encephalopathy, 84 · score 0.76
Epileptic encephalopathy · score 0.49
neurodegenerative disease · score 0.34
Herpes Zoster · score 0.29
response to tofacitinib · score 0.29
West syndrome · score 0.27
neuroinflammatory disorder · score 0.25
traffic air pollution measurement · score 0.23
peripheral arterial disease · score 0.23
glioblastoma multiforme · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60701-F1	alphafold	PREDICTED	93.87	—

Amino-acid sequence (494 residues)

MFEIKKICCI GAGYVGGPTC SVIAHMCPEI RVTVVDVNES RINAWNSPTL PIYEPGLKEV VESCRGKNLF FSTNIDDAIK EADLVFISVN TPTKTYGMGK GRAADLKYIE ACARRIVQNS NGYKIVTEKS TVPVRAAESI RRIFDANTKP NLNLQVLSNP EFLAEGTAIK DLKNPDRVLI GGDETPEGQR AVQALCAVYE HWVPREKILT TNTWSSELSK LAANAFLAQR ISSINSISAL CEATGADVEE VATAIGMDQR IGNKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVARYW QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS IYISKYLMDE GAHLHIYDPK VPREQIVVDL SHPGVSEDDQ VSRLVTISKD PYEACDGAHA VVICTEWDMF KELDYERIHK KMLKPAFIFD GRRVLDGLHN ELQTIGFQIE TIGKKVSSKR IPYAPSGEIP KFSLQDPPNK KPKV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards