Protein-tyrosine sulfotransferase 2 (TPST2)

About Protein-tyrosine sulfotransferase 2

Protein-tyrosine sulfotransferase 2 (TPST2) is a protein from Homo sapiens identified by UniProt accession O60704, 377 residues long. MolForge cross-references it against 0 known binders and 169 disease associations.

Target properties

Protein name	Protein-tyrosine sulfotransferase 2
UniProt accession	O60704
Gene	TPST2
Organism	Homo sapiens
Length	377 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (169)

Diseases linked to this target (Open Targets).

multiple sclerosis · score 0.34
lysosomal storage disease · score 0.34
Parkinson disease · score 0.34
neurodegenerative disease · score 0.34
Alzheimer disease · score 0.34
cognitive function measurement · score 0.32
episodic memory · score 0.29
blood protein measurement · score 0.23
Abnormality of refraction · score 0.15
diet measurement · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60704-F1	alphafold	PREDICTED	90.93	—

Amino-acid sequence (377 residues)

MRLSVRRVLL AAGCALVLVL AVQLGQQVLE CRAVLAGLRS PRGAMRPEQE ELVMVGTNHV EYRYGKAMPL IFVGGVPRSG TTLMRAMLDA HPEVRCGEET RIIPRVLAMR QAWSKSGREK LRLDEAGVTD EVLDAAMQAF ILEVIAKHGE PARVLCNKDP FTLKSSVYLS RLFPNSKFLL MVRDGRASVH SMITRKVTIA GFDLSSYRDC LTKWNKAIEV MYAQCMEVGK EKCLPVYYEQ LVLHPRRSLK LILDFLGIAW SDAVLHHEDL IGKPGGVSLS KIERSTDQVI KPVNLEALSK WTGHIPGDVV RDMAQIAPML AQLGYDPYAN PPNYGNPDPF VINNTQRVLK GDYKTPANLK GYFQVNQNST SSHLGSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards