About Leupaxin
Leupaxin (LPXN) is a protein
from Homo sapiens identified by UniProt accession
O60711, 386 residues long.
MolForge cross-references it against 0 known binders and
128 disease associations.
Target properties
| Protein name | Leupaxin |
|---|
| UniProt accession | O60711 |
|---|
| Gene | LPXN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 386 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (128)
Diseases linked to this target (Open Targets).
- mathematical ability · score 0.17
- appendicular lean mass · score 0.14
- platelet count · score 0.13
- serum gamma-glutamyl transferase measurement · score 0.11
- heel bone mineral density · score 0.09
- monocyte count · score 0.08
- high density lipoprotein cholesterol measurement · score 0.08
- breast cancer · score 0.07
- chronotype measurement · score 0.07
- cardiovascular disease · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60711-F1 | alphafold | PREDICTED | 76.37 | — |
Amino-acid sequence (386 residues)
MEELDALLEE LERSTLQDSD EYSNPAPLPL DQHSRKETNL DETSEILSIQ DNTSPLPAQL VYTTNIQELN VYSEAQEPKE SPPPSKTSAA AQLDELMAHL TEMQAKVAVR ADAGKKHLPD KQDHKASLDS MLGGLEQELQ DLGIATVPKG HCASCQKPIA GKVIHALGQS WHPEHFVCTH CKEEIGSSPF FERSGLAYCP NDYHQLFSPR CAYCAAPILD KVLTAMNQTW HPEHFFCSHC GEVFGAEGFH EKDKKPYCRK DFLAMFSPKC GGCNRPVLEN YLSAMDTVWH PECFVCGDCF TSFSTGSFFE LDGRPFCELH YHHRRGTLCH GCGQPITGRC ISAMGYKFHP EHFVCAFCLT QLSKGIFREQ NDKTYCQPCF NKLFPL
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