Protein-S-isoprenylcysteine O-methyltransferase (ICMT)

About Protein-S-isoprenylcysteine O-methyltransferase

Protein-S-isoprenylcysteine O-methyltransferase (ICMT) is a protein from Homo sapiens identified by UniProt accession O60725, 284 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	Protein-S-isoprenylcysteine O-methyltransferase
UniProt accession	O60725
Gene	ICMT
Organism	Homo sapiens
Length	284 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

cancer · score 0.38
diet measurement · score 0.20
resting heart rate · score 0.12
pulse pressure measurement · score 0.11
QT interval · score 0.08
T wave morphology measurement · score 0.06
electrocardiography · score 0.06
ulcerative colitis · score 0.04
oral squamous cell carcinoma · score 0.03
hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60725-F1	alphafold	PREDICTED	93.13	—

Amino-acid sequence (284 residues)

MAGCAARAPP GSEARLSLAT FLLGASVLAL PLLTRAGLQG RTGLALYVAG LNALLLLLYR PPRYQIAIRA CFLGFVFGCG TLLSFSQSSW SHFGWYMCSL SLFHYSEYLV TAVNNPKSLS LDSFLLNHSL EYTVAALSSW LEFTLENIFW PELKQITWLS VTGLLMVVFG ECLRKAAMFT AGSNFNHVVQ NEKSDTHTLV TSGVYAWFRH PSYVGWFYWS IGTQVMLCNP ICGVSYALTV WRFFRDRTEE EEISLIHFFG EEYLEYKKRV PTGLPFIKGV KVDL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards