Dual specificity protein phosphatase CDC14B (CDC14B)

About Dual specificity protein phosphatase CDC14B

Dual specificity protein phosphatase CDC14B (CDC14B) is a protein from Homo sapiens identified by UniProt accession O60729, 498 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.

Target properties

Protein name	Dual specificity protein phosphatase CDC14B
UniProt accession	O60729
Gene	CDC14B
Organism	Homo sapiens
Length	498 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (61)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
platelet count · score 0.33
mathematical ability · score 0.22
appendicular lean mass · score 0.21
neuroinflammatory disorder · score 0.18
intelligence · score 0.17
electrocardiography · score 0.15
cognitive function measurement · score 0.15
self reported educational attainment · score 0.14
vital capacity · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60729-F1	alphafold	PREDICTED	80.25	—

Amino-acid sequence (498 residues)

MKRKSERRSS WAAAPPCSRR CSSTSPGVKK IRSSTQQDPR RRDPQDDVYL DITDRLCFAI LYSRPKSASN VHYFSIDNEL EYENFYADFG PLNLAMVYRY CCKINKKLKS ITMLRKKIVH FTGSDQRKQA NAAFLVGCYM VIYLGRTPEE AYRILIFGET SYIPFRDAAY GSCNFYITLL DCFHAVKKAM QYGFLNFNSF NLDEYEHYEK AENGDLNWII PDRFIAFCGP HSRARLESGY HQHSPETYIQ YFKNHNVTTI IRLNKRMYDA KRFTDAGFDH HDLFFADGST PTDAIVKEFL DICENAEGAI AVHCKAGLGR TGTLIACYIM KHYRMTAAET IAWVRICRPG SVIGPQQQFL VMKQTNLWLE GDYFRQKLKG QENGQHRAAF SKLLSGVDDI SINGVENQDQ QEPEPYSDDD EINGVTQGDR LRALKSRRQS KTNAIPLTVI LQSSVQSCKT SEPNISGSAG ITKRTTRSAS RKSSVKSLSI SRTKTVLR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards