About 85/88 kDa calcium-independent phospholipase A2
85/88 kDa calcium-independent phospholipase A2 (PLA2G6) is a protein
from Homo sapiens identified by UniProt accession
O60733, 806 residues long.
MolForge cross-references it against 0 known binders and
470 disease associations.
Target properties
| Protein name | 85/88 kDa calcium-independent phospholipase A2 |
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| UniProt accession | O60733 |
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| Gene | PLA2G6 |
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| Organism | Homo sapiens |
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| Length | 806 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (470)
Diseases linked to this target (Open Targets).
- neurodegeneration with brain iron accumulation 2A · score 0.84
- Adult-onset dystonia-parkinsonism · score 0.76
- autosomal recessive Parkinson disease 14 · score 0.76
- PLA2G6-associated neurodegeneration · score 0.72
- Parkinson disease · score 0.57
- Iron accumulation in brain · score 0.55
- neurodegeneration with brain iron accumulation · score 0.54
- genetic disorder · score 0.53
- Abnormality of the nervous system · score 0.48
- spastic ataxia · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
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| AF-O60733-F1 | alphafold | PREDICTED | 86.14 | — |
Amino-acid sequence (806 residues)
MQFFGRLVNT FSGVTNLFSN PFRVKEVAVA DYTSSDRVRE EGQLILFQNT PNRTWDCVLV NPRNSQSGFR LFQLELEADA LVNFHQYSSQ LLPFYESSPQ VLHTEVLQHL TDLIRNHPSW SVAHLAVELG IRECFHHSRI ISCANCAENE EGCTPLHLAC RKGDGEILVE LVQYCHTQMD VTDYKGETVF HYAVQGDNSQ VLQLLGRNAV AGLNQVNNQG LTPLHLACQL GKQEMVRVLL LCNARCNIMG PNGYPIHSAM KFSQKGCAEM IISMDSSQIH SKDPRYGASP LHWAKNAEMA RMLLKRGCNV NSTSSAGNTA LHVAVMRNRF DCAIVLLTHG ANADARGEHG NTPLHLAMSK DNVEMIKALI VFGAEVDTPN DFGETPTFLA SKIGRLVTRK AILTLLRTVG AEYCFPPIHG VPAEQGSAAP HHPFSLERAQ PPPISLNNLE LQDLMHISRA RKPAFILGSM RDEKRTHDHL LCLDGGGVKG LIIIQLLIAI EKASGVATKD LFDWVAGTST GGILALAILH SKSMAYMRGM YFRMKDEVFR GSRPYESGPL EEFLKREFGE HTKMTDVRKP KVMLTGTLSD RQPAELHLFR NYDAPETVRE PRFNQNVNLR PPAQPSDQLV WRAARSSGAA PTYFRPNGRF LDGGLLANNP TLDAMTEIHE YNQDLIRKGQ ANKVKKLSIV VSLGTGRSPQ VPVTCVDVFR PSNPWELAKT VFGAKELGKM VVDCCTDPDG RAVDRARAWC EMVGIQYFRL NPQLGTDIML DEVSDTVLVN ALWETEVYIY EHREEFQKLI QLLLSP
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