Galanin receptor type 3 (GALR3)

About Galanin receptor type 3

Galanin receptor type 3 (GALR3) is a protein from Homo sapiens identified by UniProt accession O60755, 368 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.

Target properties

Protein name	Galanin receptor type 3
UniProt accession	O60755
Gene	GALR3
Organism	Homo sapiens
Length	368 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (61)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.12
colitis · score 0.07
Asperger syndrome · score 0.06
neoplasm · score 0.05
hypertriglyceridemia 2 · score 0.05
autism · score 0.05
bone quantitative ultrasound measurement · score 0.05
autism spectrum disorder · score 0.04
body height · score 0.04
15q11q13 microduplication syndrome · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60755-F1	alphafold	PREDICTED	80.99	—

Amino-acid sequence (368 residues)

MADAQNISLD SPGSVGAVAV PVVFALIFLL GTVGNGLVLA VLLQPGPSAW QEPGSTTDLF ILNLAVADLC FILCCVPFQA TIYTLDAWLF GALVCKAVHL LIYLTMYASS FTLAAVSVDR YLAVRHPLRS RALRTPRNAR AAVGLVWLLA ALFSAPYLSY YGTVRYGALE LCVPAWEDAR RRALDVATFA AGYLLPVAVV SLAYGRTLRF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV AALYALCWGP HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YALASRHFRA RFRRLWPCGR RRRHRARRAL RRVRPASSGP PGCPGDARPS GRLLAGGGQG PEPREGPVHG GEAARGPE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards