About Hematopoietic prostaglandin D synthase
Hematopoietic prostaglandin D synthase (HPGDS) is a protein
from Homo sapiens identified by UniProt accession
O60760, 199 residues long.
MolForge cross-references it against 0 known binders and
735 disease associations.
Target properties
| Protein name | Hematopoietic prostaglandin D synthase |
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| UniProt accession | O60760 |
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| Gene | HPGDS |
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| Organism | Homo sapiens |
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| Length | 199 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (735)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.43
- age at menarche · score 0.37
- mean platelet volume · score 0.28
- bone quantitative ultrasound measurement · score 0.19
- high density lipoprotein cholesterol measurement · score 0.16
- heel bone mineral density · score 0.16
- puberty onset measurement · score 0.12
- neurodegenerative disease · score 0.11
- diastolic blood pressure · score 0.10
- neoplasm · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60760-F1 | alphafold | PREDICTED | 97.31 | — |
Amino-acid sequence (199 residues)
MPNYKLTYFN MRGRAEIIRY IFAYLDIQYE DHRIEQADWP EIKSTLPFGK IPILEVDGLT LHQSLAIARY LTKNTDLAGN TEMEQCHVDA IVDTLDDFMS CFPWAEKKQD VKEQMFNELL TYNAPHLMQD LDTYLGGREW LIGNSVTWAD FYWEICSTTL LVFKPDLLDN HPRLVTLRKK VQAIPAVANW IKRRPQTKL
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