About Zinc finger protein 354A
Zinc finger protein 354A (ZNF354A) is a protein
from Homo sapiens identified by UniProt accession
O60765, 605 residues long.
MolForge cross-references it against 0 known binders and
43 disease associations.
Target properties
| Protein name | Zinc finger protein 354A |
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| UniProt accession | O60765 |
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| Gene | ZNF354A |
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| Organism | Homo sapiens |
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| Length | 605 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (43)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.22
- granulocyte percentage of myeloid white cells · score 0.07
- neutrophil percentage of leukocytes · score 0.05
- Hyperlipoproteinemia type 1 · score 0.05
- kidney disease · score 0.04
- hepatorenocardiac degenerative fibrosis · score 0.04
- Hepatic veno-occlusive disease - immunodeficiency · score 0.04
- Senior-Boichis syndrome · score 0.04
- immunodeficiency 75 · score 0.04
- idiopathic hypereosinophilic syndrome · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60765-F1 | alphafold | PREDICTED | 68.42 | — |
Amino-acid sequence (605 residues)
MAAGQREARP QVSLTFEDVA VLFTRDEWRK LAPSQRNLYR DVMLENYRNL VSLGLPFTKP KVISLLQQGE DPWEVEKDGS GVSSLGSKSS HKTTKSTQTQ DSSFQGLILK RSNRNVPWDL KLEKPYIYEG RLEKKQDKKG SFQIVSATHK KIPTIERSHK NTELSQNFSP KSVLIRQQIL PREKTPPKCE IQGNSLKQNS QLLNQPKITA DKRYKCSLCE KTFINTSSLR KHEKNHSGEK LFKCKECSKA FSQSSALIQH QITHTGEKPY ICKECGKAFT LSTSLYKHLR THTVEKSYRC KECGKSFSRR SGLFIHQKIH AEENPCKYNP GRKASSCSTS LSGCQRIHSR KKSYLCNECG NTFKSSSSLR YHQRIHTGEK PFKCSECGRA FSQSASLIQH ERIHTGEKPY RCNECGKGFT SISRLNRHRI IHTGEKFYNC NECGKALSSH STLIIHERIH TGEKPCKCKV CGKAFRQSSA LIQHQRMHTG ERPYKCNECG KTFRCNSSLS NHQRIHTGEK PYRCEECGIS FGQSSALIQH RRIHTGEKPF KCNTCGKTFR QSSSRIAHQR IHTGEKPYEC NTCGKLFNHR SSLTNHYKIH IEEDP
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