Small ribosomal subunit protein uS14m (MRPS14)

About Small ribosomal subunit protein uS14m

Small ribosomal subunit protein uS14m (MRPS14) is a protein from Homo sapiens identified by UniProt accession O60783, 128 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	Small ribosomal subunit protein uS14m
UniProt accession	O60783
Gene	MRPS14
Organism	Homo sapiens
Length	128 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.36
combined oxidative phosphorylation deficiency · score 0.33
platelet count · score 0.23
erythrocyte count · score 0.21
keratoconus · score 0.17
platelet component distribution width · score 0.14
neutrophil count · score 0.13
urate measurement · score 0.11
bone density · score 0.11
myeloid white cell count · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60783-F1	alphafold	PREDICTED	86.21	—

Amino-acid sequence (128 residues)

MAAFMLGSLL RTFKQMVPSS ASGQVRSHYV DWRMWRDVKR RKMAYEYADE RLRINSLRKN TILPKILQDV ADEEIAALPR DSCPVRIRNR CVMTSRPRGV KRRWRLSRIV FRHLADHGQL SGIQRATW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards