T-box transcription factor TBX19 (TBX19)

About T-box transcription factor TBX19

T-box transcription factor TBX19 (TBX19) is a protein from Homo sapiens identified by UniProt accession O60806, 448 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.

Target properties

Protein name	T-box transcription factor TBX19
UniProt accession	O60806
Gene	TBX19
Organism	Homo sapiens
Length	448 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (110)

Diseases linked to this target (Open Targets).

Adrenocorticotropic hormone deficiency · score 0.72
genetic disorder · score 0.41
lymphedema, hereditary, iii · score 0.27
neutrophil count · score 0.24
pituitary stalk interruption syndrome · score 0.13
testosterone measurement · score 0.09
neoplasm · score 0.09
PHF-tau measurement · score 0.06
familial glucocorticoid deficiency · score 0.06
obesity due to pro-opiomelanocortin deficiency · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60806-F1	alphafold	PREDICTED	62.74	—

Amino-acid sequence (448 residues)

MAMSELGTRK PSDGTVSHLL NVVESELQAG REKGDPTEKQ LQIILEDAPL WQRFKEVTNE MIVTKNGRRM FPVLKISVTG LDPNAMYSLL LDFVPTDSHR WKYVNGEWVP AGKPEVSSHS CVYIHPDSPN FGAHWMKAPI SFSKVKLTNK LNGGGQIMLN SLHKYEPQVH IVRVGSAHRM VTNCSFPETQ FIAVTAYQNE EITALKIKYN PFAKAFLDAK ERNHLRDVPE AISESQHVTY SHLGGWIFSN PDGVCTAGNS NYQYAAPLPL PAPHTHHGCE HYSGLRGHRQ APYPSAYMHR NHSPSVNLIE SSSNNLQVFS GPDSWTSLSS TPHASILSVP HTNGPINPGP SPYPCLWTIS NGAGGPSGPG PEVHASTPGA FLLGNPAVTS PPSVLSTQAP TSAGVEVLGE PSLTSIAVST WTAVASHPFA GWGGPGAGGH HSPSSLDG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards