PRAME family member 10 (PRAMEF10)

About PRAME family member 10

PRAME family member 10 (PRAMEF10) is a protein from Homo sapiens identified by UniProt accession O60809, 474 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.

Target properties

Protein name	PRAME family member 10
UniProt accession	O60809
Gene	PRAMEF10
Organism	Homo sapiens
Length	474 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (102)

Diseases linked to this target (Open Targets).

azoospermia · score 0.09
partial chromosome Y deletion · score 0.08
spermatogenic failures 50 · score 0.08
spermatogenic failure, X-linked, 2 · score 0.08
spermatogenic failure 25 · score 0.08
spermatogenic failure 63 · score 0.07
isochromosomy Yp · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
spermatogenic failure 61 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60809-F1	alphafold	PREDICTED	76.72	—

Amino-acid sequence (474 residues)

MSLQAPSRLL ELAGQSLLRN QFLTIFTLDE LPREVFPLMF MEAFSMRRFE ALKLMVQAWP FLRLPLGSLM KTPHLETLQA VLRGLDTLVA QKVRPRRWKL QVLDLRDVDE NFWTIWSGAR VLSCSPEAMS KRQTVEDCPR MGERQPLKVF IDLCLKESTL DECLSYLFGW IHYRRGLVHL CCSKVQNYSM PTSSFRNLLE RIYPDSIQEL EVWKKCSLNK TGKFAPYLSQ MSNLRELFLA FGYERELYVS VQWPCIPDLD SPFLCLYYPQ MLYIKKISNI KEHLEHLLRY LKNPLGAFIF SDAYLTDRDM ECLSQYPSLS QLKELRLIHI LMWTTNLEPL GVLLEKVAAT LKTLVLKDCR IQDPQLRVLL PALSHCSQLT TFNFHGNETS MNALKDLLRH TRGLSKLGLE LYPAPLESLD YKGHVNWEIL TPIRAELMRT LREVRQPKRI FFGPVPCPNC GSWPSEKVDF HLCS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards