PRAME family member 4 (PRAMEF4)

About PRAME family member 4

PRAME family member 4 (PRAMEF4) is a protein from Homo sapiens identified by UniProt accession O60810, 478 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.

Target properties

Protein name	PRAME family member 4
UniProt accession	O60810
Gene	PRAMEF4
Organism	Homo sapiens
Length	478 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (108)

Diseases linked to this target (Open Targets).

azoospermia · score 0.09
partial chromosome Y deletion · score 0.08
spermatogenic failures 50 · score 0.08
spermatogenic failure, X-linked, 2 · score 0.08
spermatogenic failure 25 · score 0.08
spermatogenic failure 63 · score 0.07
isochromosomy Yp · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
spermatogenic failure 61 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60810-F1	alphafold	PREDICTED	84.52	—

Amino-acid sequence (478 residues)

MKMSIWTPPR LLELAGRSLL RDQALAMSTL EELPTELFPP LFMEAFSRRR CEALKLMVQS WPFRRLPLRP LIKMPCLEAF QAVLDGLDAL LNLGVRPRRW KLQVLDLQDV CENFWMVWSE AMAHGCFLNA KRNKKPVEDC PRMKGRQPLT VFVELWLKNR TLDEYLTCLL LWVKQRKDLL HLCCKKLKIL GMPFRNIRSI LKMVNLDCIQ EVEVNCKWVL PILTQFTPYL GHMRNLQKLI LSHMDVSRYV SPEQKKEIVT QFTTQFLKLR CLQKLYMNSV SFLEGHLDQL LSCLKTSLKF LTITNCVLLE SDLKHLSQCP SISQLKTLDL SGIRLTNYSL VPLQILLEKV AATLEYLDLD DCGIIDSQVN AILPALSRCF ELNTFSFCGN PICMATLENL LSHTIILKNL CVELYPAPRE SYGADGTLCW SRFAQIRAEL MNRVRDLRHP KRILFCTDYC PDCGNRSFYD LEADQYCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards