About PRAME family member 11
PRAME family member 11 (PRAMEF11) is a protein
from Homo sapiens identified by UniProt accession
O60813, 478 residues long.
MolForge cross-references it against 0 known binders and
103 disease associations.
Target properties
| Protein name | PRAME family member 11 |
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| UniProt accession | O60813 |
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| Gene | PRAMEF11 |
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| Organism | Homo sapiens |
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| Length | 478 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (103)
Diseases linked to this target (Open Targets).
- optic cup area measurement · score 0.13
- azoospermia · score 0.09
- partial chromosome Y deletion · score 0.08
- spermatogenic failures 50 · score 0.08
- spermatogenic failure, X-linked, 2 · score 0.08
- spermatogenic failure 25 · score 0.08
- spermatogenic failure 63 · score 0.07
- isochromosomy Yp · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60813-F1 | alphafold | PREDICTED | 84.23 | — |
Amino-acid sequence (478 residues)
MKMSIRIPPR LLELAGRSLL RDQALAVSTL EELPTELFPP LFMEAFSRRR CEALKLMVQA WPFRRLPLRP LIKMPCLEAF QAVLDGLDAL LTQGVRPRRW KLQVLDLQDV CENFWMVWSE AMAHGCFLNA KRNKKPVQDC PRMRGRQPLT VFVELWLKNR TLDEYLTCLL LWVKQRRDLL HLCCKKLKIL GMPFRNIRSI LKMVNLDCIQ EVEVNCKWIL PILTQFTPYL GHLRNLQKLV LSHMDVSRYV SPEQKKEIVT QFTTQFLKLR CLQKLYMNSV SFLEGHLDQL LSCLKTSLKV LTITNCVLLE SDLKHLSQCP SISQLKTLDL SGIRLTNYSL VPLQILLEKV AATLEYLDLD DCGIIDSQVN AILPALSRCF ELNTFSFCGN PICMATLENL LSHTIILKNL CLELYPAPQE SYGADGTLCW SRFAQIRAEL MKKVRHLRHP KRILFCTDNC PDHGDRSFYD LEADQYCC
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