Histone H2B type 1-K (H2BC12)

About Histone H2B type 1-K

Histone H2B type 1-K (H2BC12) is a protein from Homo sapiens identified by UniProt accession O60814, 126 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

Target properties

Protein name	Histone H2B type 1-K
UniProt accession	O60814
Gene	H2BC12
Organism	Homo sapiens
Length	126 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (63)

Diseases linked to this target (Open Targets).

viral disease · score 0.50
infectious disease · score 0.50
cancer · score 0.37
melanoma · score 0.37
breast carcinoma · score 0.37
schizophrenia · score 0.21
intelligence · score 0.20
systolic blood pressure · score 0.16
mineral metabolism disease · score 0.13
hyperthyroidism · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60814-F1	alphafold	PREDICTED	87.80	—

Amino-acid sequence (126 residues)

MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT KYTSAK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards