About Coiled-coil domain-containing protein 22
Coiled-coil domain-containing protein 22 (CCDC22) is a protein
from Homo sapiens identified by UniProt accession
O60826, 627 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Coiled-coil domain-containing protein 22 |
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| UniProt accession | O60826 |
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| Gene | CCDC22 |
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| Organism | Homo sapiens |
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| Length | 627 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (33)
Diseases linked to this target (Open Targets).
- 3C syndrome · score 0.66
- X-linked syndromic intellectual disability · score 0.57
- neurodegenerative disease · score 0.55
- lysosomal storage disease · score 0.36
- immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome · score 0.12
- Ritscher-Schinzel syndrome · score 0.01
- endometriosis · score 0.01
- systemic juvenile idiopathic arthritis · score 0.01
- hemophagocytic syndrome · score 0.01
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60826-F1 | alphafold | PREDICTED | 78.55 | — |
Amino-acid sequence (627 residues)
MEEADRILIH SLRQAGTAVP PDVQTLRAFT TELVVEAVVR CLRVINPAVG SGLSPLLPLA MSARFRLAMS LAQACMDLGY PLELGYQNFL YPSEPDLRDL LLFLAERLPT DASEDADQPA GDSAILLRAI GSQIRDQLAL PWVPPHLRTP KLQHLQGSAL QKPFHASRLV VPELSSRGEP REFQASPLLL PVPTQVPQPV GRVASLLEHH ALQLCQQTGR DRPGDEDWVH RTSRLPPQED TRAQRQRLQK QLTEHLRQSW GLLGAPIQAR DLGELLQAWG AGAKTGAPKG SRFTHSEKFT FHLEPQAQAT QVSDVPATSR RPEQVTWAAQ EQELESLREQ LEGVNRSIEE VEADMKTLGV SFVQAESECR HSKLSTAERE QALRLKSRAV ELLPDGTANL AKLQLVVENS AQRVIHLAGQ WEKHRVPLLA EYRHLRKLQD CRELESSRRL AEIQELHQSV RAAAEEARRK EEVYKQLMSE LETLPRDVSR LAYTQRILEI VGNIRKQKEE ITKILSDTKE LQKEINSLSG KLDRTFAVTD ELVFKDAKKD DAVRKAYKYL AALHENCSQL IQTIEDTGTI MREVRDLEEQ IETELGKKTL SNLEKIREDY RALRQENAGL LGRVREA
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