Polyglutamine-binding protein 1 (PQBP1)

About Polyglutamine-binding protein 1

Polyglutamine-binding protein 1 (PQBP1) is a protein from Homo sapiens identified by UniProt accession O60828, 265 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.

Target properties

Protein name	Polyglutamine-binding protein 1
UniProt accession	O60828
Gene	PQBP1
Organism	Homo sapiens
Length	265 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (78)

Diseases linked to this target (Open Targets).

Renpenning syndrome · score 0.79
neurodegenerative disease · score 0.53
genetic disorder · score 0.46
Microcephaly · score 0.42
X-linked intellectual disability, Sutherland-Haan type · score 0.37
X-linked intellectual disability, Porteous type · score 0.37
X-linked intellectual disability, Golabi-Ito-hall type · score 0.37
hamel cerebro-palato-cardiac syndrome · score 0.37
Intellectual disability · score 0.34
Hyperactivity · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60828-F1	alphafold	PREDICTED	70.54	—

Amino-acid sequence (265 residues)

MPLPVALQTR LAKRGILKHL EPEPEEEIIA EDYDDDPVDY EATRLEGLPP SWYKVFDPSC GLPYYWNADT DLVSWLSPHD PNSVVTKSAK KLRSSNADAE EKLDRSHDKS DRGHDKSDRS HEKLDRGHDK SDRGHDKSDR DRERGYDKVD RERERDRERD RDRGYDKADR EEGKERRHHR REELAPYPKS KKAVSRKDEE LDPMDPSSYS DAPRGTWSTG LPKRNEAKTG ADTTAAGPLF QQRPYPSPGA VLRANAEASR TKQQD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards