About Mitochondrial import inner membrane translocase subunit Tim17-B
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) is a protein
from Homo sapiens identified by UniProt accession
O60830, 172 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Mitochondrial import inner membrane translocase subunit Tim17-B |
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| UniProt accession | O60830 |
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| Gene | TIMM17B |
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| Organism | Homo sapiens |
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| Length | 172 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (33)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- essential thrombocythemia · score 0.05
- Crigler-Najjar syndrome type 2 · score 0.05
- Rh deficiency syndrome · score 0.05
- thrombocythemia 2 · score 0.05
- gluthathione peroxidase deficiency · score 0.05
- hemolytic anemia due to erythrocyte adenosine deaminase overproduction · score 0.04
- elliptocytosis 2 · score 0.04
- familial isolated congenital asplenia · score 0.04
- primary familial polycythemia due to EPO receptor mutation · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60830-F1 | alphafold | PREDICTED | 82.30 | — |
Amino-acid sequence (172 residues)
MEEYAREPCP WRIVDDCGGA FTMGVIGGGV FQAIKGFRNA PVGIRHRLRG SANAVRIRAP QIGGSFAVWG GLFSTIDCGL VRLRGKEDPW NSITSGALTG AVLAARSGPL AMVGSAMMGG ILLALIEGVG ILLTRYTAQQ FRNAPPFLED PSQLPPKDGT PAPGYPSYQQ YH
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