PRA1 family protein 2 (PRAF2)

About PRA1 family protein 2

PRA1 family protein 2 (PRAF2) is a protein from Homo sapiens identified by UniProt accession O60831, 178 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.

Target properties

Protein name	PRA1 family protein 2
UniProt accession	O60831
Gene	PRAF2
Organism	Homo sapiens
Length	178 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (25)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.52
lysosomal storage disease · score 0.37
hepatocellular carcinoma · score 0.08
esophageal squamous cell carcinoma · score 0.07
neoplasm · score 0.04
cancer · score 0.04
neuroblastoma · score 0.03
malignant glioma · score 0.01
gonorrhea · score 0.01
calf circumference measurement · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60831-F1	alphafold	PREDICTED	83.74	—

Amino-acid sequence (178 residues)

MSEVRLPPLR ALDDFVLGSA RLAAPDPCDP QRWCHRVINN LLYYQTNYLL CFGIGLALAG YVRPLHTLLS ALVVAVALGV LVWAAETRAA VRRCRRSHPA ACLAAVLAVG LLVLWVAGGA CTFLFSIAGP VLLILVHASL RLRNLKNKIE NKIESIGLKR TPMGLLLEAL GQEQEAGS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards