About H/ACA ribonucleoprotein complex subunit DKC1
H/ACA ribonucleoprotein complex subunit DKC1 (DKC1) is a protein
from Homo sapiens identified by UniProt accession
O60832, 514 residues long.
MolForge cross-references it against 0 known binders and
187 disease associations.
Target properties
| Protein name | H/ACA ribonucleoprotein complex subunit DKC1 |
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| UniProt accession | O60832 |
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| Gene | DKC1 |
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| Organism | Homo sapiens |
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| Length | 514 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (187)
Diseases linked to this target (Open Targets).
- dyskeratosis congenita, X-linked · score 0.86
- dyskeratosis congenita · score 0.73
- Hoyeraal-Hreidarsson syndrome · score 0.57
- neurodegenerative disease · score 0.52
- cataracts, hearing impairment, nephrotic syndrome, and enterocolitis 1 · score 0.45
- DKC1-related disorder · score 0.41
- isolated cerebellar hypoplasia/agenesis · score 0.26
- endometrial cancer · score 0.19
- pulmonary fibrosis · score 0.14
- breast adenocarcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O60832-F1 | alphafold | PREDICTED | 79.42 | — |
Amino-acid sequence (514 residues)
MADAEVIILP KKHKKKKERK SLPEEDVAEI QHAEEFLIKP ESKVAKLDTS QWPLLLKNFD KLNVRTTHYT PLACGSNPLK REIGDYIRTG FINLDKPSNP SSHEVVAWIR RILRVEKTGH SGTLDPKVTG CLIVCIERAT RLVKSQQSAG KEYVGIVRLH NAIEGGTQLS RALETLTGAL FQRPPLIAAV KRQLRVRTIY ESKMIEYDPE RRLGIFWVSC EAGTYIRTLC VHLGLLLGVG GQMQELRRVR SGVMSEKDHM VTMHDVLDAQ WLYDNHKDES YLRRVVYPLE KLLTSHKRLV MKDSAVNAIC YGAKIMLPGV LRYEDGIEVN QEIVVITTKG EAICMAIALM TTAVISTCDH GIVAKIKRVI MERDTYPRKW GLGPKASQKK LMIKQGLLDK HGKPTDSTPA TWKQEYVDYS ESAKKEVVAE VVKAPQVVAE AAKTAKRKRE SESESDETPP AAPQLIKKEK KKSKKDKKAK AGLESGAEPG DGDSDTTKKK KKKKKAKEVE LVSE
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