E3 ubiquitin-protein ligase TRIM13 (TRIM13)

About E3 ubiquitin-protein ligase TRIM13

E3 ubiquitin-protein ligase TRIM13 (TRIM13) is a protein from Homo sapiens identified by UniProt accession O60858, 407 residues long. MolForge cross-references it against 0 known binders and 149 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase TRIM13
UniProt accession	O60858
Gene	TRIM13
Organism	Homo sapiens
Length	407 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (149)

Diseases linked to this target (Open Targets).

vital capacity · score 0.28
heel bone mineral density · score 0.28
BMI-adjusted waist-hip ratio · score 0.28
forced expiratory volume · score 0.26
appendicular lean mass · score 0.24
sex hormone-binding globulin measurement · score 0.23
body height · score 0.22
lean body mass · score 0.20
whole body water mass · score 0.20
bone quantitative ultrasound measurement · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O60858-F1	alphafold	PREDICTED	79.27	—

Amino-acid sequence (407 residues)

MELLEEDLTC PICCSLFDDP RVLPCSHNFC KKCLEGILEG SVRNSLWRPA PFKCPTCRKE TSATGINSLQ VNYSLKGIVE KYNKIKISPK MPVCKGHLGQ PLNIFCLTDM QLICGICATR GEHTKHVFCS IEDAYAQERD AFESLFQSFE TWRRGDALSR LDTLETSKRK SLQLLTKDSD KVKEFFEKLQ HTLDQKKNEI LSDFETMKLA VMQAYDPEIN KLNTILQEQR MAFNIAEAFK DVSEPIVFLQ QMQEFREKIK VIKETPLPPS NLPASPLMKN FDTSQWEDIK LVDVDKLSLP QDTGTFISKI PWSFYKLFLL ILLLGLVIVF GPTMFLEWSL FDDLATWKGC LSNFSSYLTK TADFIEQSVF YWEQVTDGFF IFNERFKNFT LVVLNNVAEF VCKYKLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards